A REVIEW: NANOPARTICLE PREPARATION FOR ANTIMICROBIAL DELIVERY IN INTRACELLULAR STAPHYLOCOCCUS AUREUS INFECTION
Staphylococcus aureus (S. aureus) is a commensal bacteria on the nose and skin of humans, but often causes repeated infections. S. aureus is classified as an intracellular bacterium and is capable of manipulating the immune system which makes treatment very difficult. The immune system plays a ma...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/63035 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Staphylococcus aureus (S. aureus) is a commensal bacteria on the nose and skin
of humans, but often causes repeated infections. S. aureus is classified as an
intracellular bacterium and is capable of manipulating the immune system which
makes treatment very difficult. The immune system plays a major role in dealing
with S. aureus infection, namely neutrophils and macrophages. Macrophages
have a major role in the dynamics of S. aureus infection. However, because of the
ability of S. aureus to manipulate the immune system, S. aureus is able to survive
in macrophages and cause repeated infections and invasion of other organs. To
overcome this, nanoparticle delivery systems targeting the immune system,
especially macrophages, must be developed. Nanoparticles are an ideal choice of
drug delivery system because they have the ability to increase intracellular
retention and increase intracellular antibacterial activity. One example is
biodegradable polymeric nanoparticles capable of increasing intracellular
accumulation and increasing the activity of the drug they contain. Where the
properties of the resulting nanoparticles can affect their interaction with the cell
surface and the characteristics of the early endosome compartment, thereby
controlling intracellular absorption and distribution. One example is the
hydrophobicity of the resulting particles. Where hydrophobic particles were found
in a relatively neutral intracellular environment (6.0 – 6.8), while hydrophilic
particles were found in a more acidic environment, namely the phagolysosomal
environment (4.6 – 5.1). In this way, it is possible to determine the intracellular
environment to be achieved with a delivery system designed so as to properly
release the loaded drug and achieve successful intracellular treatment.
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