KAJIAN PUSTAKA AKTIVITAS ANTIBAKTERI TUMBUHAN INDONESIA TERHADAP BAKTERI METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)

• Main Author: Agung Nugroho, Bagas
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/63080
• Institution: Institut Teknologi Bandung

The increasing use of irrational antibiotics has led to high cases of antibiotic-resistant bacteria. One of the bacteria that has received WHO supervision is methicillin-resistant Stayphylococcus aureus (MRSA). Cases of MRSA infection are increasing but the development of new types of antibiotics is increasingly limited. Therefore, the discovery of new types of antibiotics from plants needs to be studied and developed. The research begins with searching scientific articles and journals on the PubMed, Google Scholar, Science Direct, and Research Gate search engines. Then, scientific articles and journals are selected based on the specified criteria. Literature search obtained 44 scientific journals that meet the criteria. The results of the literature review show that plants have the potential to be developed as a source of new antibiotics. The plant species discussed are plant species from the Acanthaceae, Amaranthaceae, Asteraceae, Bignoniaceae, Chrysobalanaceae, Clusiaceae, Euphorbiaceae, Fabaceae, Lamiaceae, Lauraceae, Lythraceae, Meliaceae, Menispermaceae, Moringaceae, Rhizoporaceae, Rubiaceae, Rutaceae, Solanaceae, and Zingiberaceae. The content of secondary metabolites such as phenols, alkaloids, flavonoid, and terpenoids play a major role in influencing the permeability of bacterial cell membranes, which will change the morphology of bacteria so that antibacterial compounds can enter bacterial cells and affect bacterial metabolism which results in disrupted bacterial growth, reduced metabolic enzymes, and leads to on bacterial death.