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Abstract: <br /> <br /> <br /> <br /> Sun exposure on skin can cause sunburn. Vitamin E is widely used in the prevention of ultravioletinduced skin damages. Photoprotective effect of vitamin E acetate formulated into SLN might increase due to its small particle size. In th...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/6410 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Abstract: <br />
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Sun exposure on skin can cause sunburn. Vitamin E is widely used in the prevention of ultravioletinduced skin damages. Photoprotective effect of vitamin E acetate formulated into SLN might increase due to its small particle size. In this research, formulation of SLN using vitamin E acetate and solid lipid cetyl alcohol was prepared using microemulsion method. Optimization of microemulsion was performed to determine optimum ratio of vitamin E acetate : cetyl alcohol and optimum amount of surfactant (Tween 80) and cosurfactant (propylene glycol). Mean diameter of SLN was measured by Zetasizer Nano. Unentrapped (free) vitamin E acetate was separated by centrifugation and entrapped amount of vitamin E acetate was measured by spectrometer UV. The amount of both surfactant and cosurfactant in the range of 6065% could form a transparent microemulsion which accommodated 6% of lipid (1% vitamin E acetate and 5% cetyl alcohol). Sonication decreased the particle size of SLN. The most optimum formula of microemulsion was 25% Tween 80, 40% propylenglikol, 1% vitamin E acetate and 5% cetyl alkohol. The mean particle diameter of SLN was 49 nm with entrapment efficiency of SLN loaded with vitamin E acetate was 84%. <br />
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