#TITLE_ALTERNATIVE#

• Main Author: Lilianna (NIM: 107 03 054), Magda
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/6410
• Institution: Institut Teknologi Bandung

Abstract: <br /> <br /> <br /> <br /> Sun exposure on skin can cause sunburn. Vitamin E is widely used in the prevention of ultravioletinduced skin damages. Photoprotective effect of vitamin E acetate formulated into SLN might increase due to its small particle size. In this research, formulation of SLN using vitamin E acetate and solid lipid cetyl alcohol was prepared using microemulsion method. Optimization of microemulsion was performed to determine optimum ratio of vitamin E acetate : cetyl alcohol and optimum amount of surfactant (Tween 80) and cosurfactant (propylene glycol). Mean diameter of SLN was measured by Zetasizer Nano. Unentrapped (free) vitamin E acetate was separated by centrifugation and entrapped amount of vitamin E acetate was measured by spectrometer UV. The amount of both surfactant and cosurfactant in the range of 6065% could form a transparent microemulsion which accommodated 6% of lipid (1% vitamin E acetate and 5% cetyl alcohol). Sonication decreased the particle size of SLN. The most optimum formula of microemulsion was 25% Tween 80, 40% propylenglikol, 1% vitamin E acetate and 5% cetyl alkohol. The mean particle diameter of SLN was 49 nm with entrapment efficiency of SLN loaded with vitamin E acetate was 84%. <br /> <br />