CASE REPORT STUDIES OF ADVERSE EFFECTS POST COVID-19 VACCINATION: A NARRATIVE REVIEW
The coronavirus disease-19 (Covid-19) pandemic that has occurred since December 2019 has changed many aspects of the health sector, one of which is the granting of approval for emergency use in vaccine development to help control the number of positive cases of Covid-19. This accelerated emerge...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/66066 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | The coronavirus disease-19 (Covid-19) pandemic that has occurred since
December 2019 has changed many aspects of the health sector, one of which is the
granting of approval for emergency use in vaccine development to help control the
number of positive cases of Covid-19. This accelerated emergency clearance raises
many questions regarding the safety and effectiveness of the vaccine due to the short
duration of the pre-marketing clinical trial phase. In terms of vaccine safety, longer
studies are needed, especially to see if there are long-term effects or unusual effects
that were not detected during pre-marketing clinical trials. This study aims to
summarize and assess the adverse effects that occur after the administration of the
Covid-19 vaccine that has obtained approval for emergency use, and to provide
initial information to health workers and preliminary evidence to conduct a more
detailed study. The search for case reports was carried out in the PubMed database
with the keyword "case report on post covid-19 vaccination". Screening for
duplication and assessment of each study was also carried out. The case findings
obtained were then grouped based on adverse effects, type of vaccine, patient
demographics, medical interventions, and end results. There were 118 case reports
of adverse effects after the Covid-19 vaccination. The most widely used type of
vaccine was mRNA vaccine (76 cases; 64,41%) and the least was inactivated virus
vaccine (3 cases; 2.54%). The most reported cases were those affecting the
cardiovascular/circulatory/lymphatic system (42 cases; 35.59%) and the least were
those affecting the respiratory system (1 case; 0.85%). A total of 89 cases were
resolved (89 cases; 75,42%), 4 cases (3.39%) with disability and 2 cases (1,69%)
of death were reported.
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