CASE REPORT STUDIES OF ADVERSE EFFECTS POST COVID-19 VACCINATION: A NARRATIVE REVIEW

• Main Author: Al Shadrina, Ainina
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/66066
• Institution: Institut Teknologi Bandung

The coronavirus disease-19 (Covid-19) pandemic that has occurred since December 2019 has changed many aspects of the health sector, one of which is the granting of approval for emergency use in vaccine development to help control the number of positive cases of Covid-19. This accelerated emergency clearance raises many questions regarding the safety and effectiveness of the vaccine due to the short duration of the pre-marketing clinical trial phase. In terms of vaccine safety, longer studies are needed, especially to see if there are long-term effects or unusual effects that were not detected during pre-marketing clinical trials. This study aims to summarize and assess the adverse effects that occur after the administration of the Covid-19 vaccine that has obtained approval for emergency use, and to provide initial information to health workers and preliminary evidence to conduct a more detailed study. The search for case reports was carried out in the PubMed database with the keyword "case report on post covid-19 vaccination". Screening for duplication and assessment of each study was also carried out. The case findings obtained were then grouped based on adverse effects, type of vaccine, patient demographics, medical interventions, and end results. There were 118 case reports of adverse effects after the Covid-19 vaccination. The most widely used type of vaccine was mRNA vaccine (76 cases; 64,41%) and the least was inactivated virus vaccine (3 cases; 2.54%). The most reported cases were those affecting the cardiovascular/circulatory/lymphatic system (42 cases; 35.59%) and the least were those affecting the respiratory system (1 case; 0.85%). A total of 89 cases were resolved (89 cases; 75,42%), 4 cases (3.39%) with disability and 2 cases (1,69%) of death were reported.