PENINGKATAN LAJU DISOLUSI TABLET NIFEDIPIN MELALUI PEMBENTUKAN DISPERSI PADAT AMORF DENGAN METODE GRANULASI BASAH
Nifedipine is a calcium channel blocker indicated for hypertension and angina. Nifedipin is a class II drug based on Biopharmaceutics Classification System. Therefore dissolution is the rate-limiting ??±?»??ð???ª?????ð??process. The objective of this study was to improve the dissolution rate of...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/66265 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Nifedipine is a calcium channel blocker indicated for hypertension and angina. Nifedipin is a class II
drug based on Biopharmaceutics Classification System. Therefore dissolution is the rate-limiting
??±?»??ð???ª?????ð??process. The objective of this study was to improve the dissolution rate of
nifedipine tablets by preparation of amorphous solid dispersions with wet granulation method.
Amorphous solid dispersion were prepared with nifedipin and PVP K-30 in various weight ratios i.e.
1:1, 1:2, 1:3, 1:4, and 1:5. The flowability of the obtained granules were evaluated by Carr Index
and Haussner Ratio determination. Moreover, the morphology and the crystalinity of the granules
were analyzed. The hardness, friability, disintegration time, and dissolution rate profile of the
tablets were determined. The increasing amount of PVP K-??ð?????± ã?ª???±??»???ªð?ð???????????
contrast, the crystalinity of the granules were decreased. The dissolution rate of the amorphous
solid dispersion tablets produced by wet granulation method was increased with increasing PVP K30 weight fractiond. The amorphous solid dispersion tablets in 1:3 weight ratio showed the highest
amount dissolved nifedipin that is 82±2,3% in 60 minutes, being the only formula that successfully
met the compendial dissolution requirement.
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