PENINGKATAN LAJU DISOLUSI TABLET NIFEDIPIN MELALUI PEMBENTUKAN DISPERSI PADAT AMORF DENGAN METODE GRANULASI BASAH

• Main Author: Sinta Kusuma, Maria
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/66265
• Institution: Institut Teknologi Bandung

Nifedipine is a calcium channel blocker indicated for hypertension and angina. Nifedipin is a class II drug based on Biopharmaceutics Classification System. Therefore dissolution is the rate-limiting ??±?»??ð???ª­?????ð??process. The objective of this study was to improve the dissolution rate of nifedipine tablets by preparation of amorphous solid dispersions with wet granulation method. Amorphous solid dispersion were prepared with nifedipin and PVP K-30 in various weight ratios i.e. 1:1, 1:2, 1:3, 1:4, and 1:5. The flowability of the obtained granules were evaluated by Carr Index and Haussner Ratio determination. Moreover, the morphology and the crystalinity of the granules were analyzed. The hardness, friability, disintegration time, and dissolution rate profile of the tablets were determined. The increasing amount of PVP K-??ð?????± ã?ª???±??»???ª­ð?ð??????????? contrast, the crystalinity of the granules were decreased. The dissolution rate of the amorphous solid dispersion tablets produced by wet granulation method was increased with increasing PVP K30 weight fractiond. The amorphous solid dispersion tablets in 1:3 weight ratio showed the highest amount dissolved nifedipin that is 82±2,3% in 60 minutes, being the only formula that successfully met the compendial dissolution requirement.