ALKALOID AND NON ALKALOID COMPOUNDS FROM STEM BARK OF NEOLITSEA JAVANICA (BLUME)
ABSTRACT: <br /> <br /> <br /> Alkaloids and sesquiterpenes are widely distributed and were reported for species of Neolitsea. One species of Indonesian plant from this genus, which is Neolitsea javanica (Blume), have never been described for its plant chemicals and biologically a...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/6807 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | ABSTRACT: <br />
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Alkaloids and sesquiterpenes are widely distributed and were reported for species of Neolitsea. One species of Indonesian plant from this genus, which is Neolitsea javanica (Blume), have never been described for its plant chemicals and biologically active constituents. Therefore, this research is designed to investigate secondary metabolites from stem bark of this plant. In the courses of that aim, extraction, partition and chromatographic purification has led to afford pure substance. The structures of isolated compounds were determined on the basis of spectroscopic techniques; UV, IR, 1H and 13C NMR, HMQC, HMBC and NOESY spectra. The efforts led to isolation of four compounds, three of them are known compounds; 3,4-dihydroxy-3,5,7-trimethoxyflavan, de-O-metilsericealactone and reticuline. Structure of another one isolated compound which is derivative of tetrahidrobenzylisokuinolin alkaloid (A1 compound) could not be suggested yet, in order it is needs further spectroscopy evidence. Flavonoids, occur in minor amounts in Neolitsea species. Flavan-3-ol was isolated for the first time from this genus. It was isolated from Cinnamomum species before. De-O-metilsericealactone appear as principal constituent of N. javanica and it was isolated for the second time from this genus. Alkaloid compounds which are derivative of tetrahidrobenzylisokuinolin are common plant chemicals from this genus. Two of these compounds, which is 3,4-dihydroxy-3,5,7-trimethoxyflavan and de-O-metilsericealactone were evaluated for their inhibitory effects on murine leukimia P388 cells with IC50 64 myu g/mL and 60 myu g/mL in a row. Based on IC50 data, suggesting that the two compound does not have inhibitory activity. This is the first report of chemical constituent of N. javanica |
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