Anti-malarial Activity of Isoquinoline Alkaloids from the Stem Bark of Actinodaphne macrophylla

• Main Authors: Mehran Fadaeinasab, -, Hairin Taha, -, Putri Narrima Mohd Fauzi, -, Hapipah Mohd Ali, -, Aty Widyawaruyanti, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: SAGE Publications Inc 2015
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/102679/1/C11-ARTIKEL.pdf; https://repository.unair.ac.id/102679/3/C11-PEER%20REVIEW.pdf; https://repository.unair.ac.id/102679/2/17%20%25%20Anti-malarial%20Activity%20of%20Isoquinoline%20Alkaloids%20from%20the%20Stem%20Bark%20of%20Actinodaphne%20macrophylla.pdf; https://repository.unair.ac.id/102679/; https://journals.sagepub.com/doi/abs/10.1177/1934578X1501000913; https://doi.org/10.1177%2F1934578X1501000913
• Institution: Universitas Airlangga

Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values of 0.08 μM, 0.05 μM, 1.18 μM, 3.11 μM, 0.65 μM, 0.26 μM, and 1.38 μM for cycleanine, 10-demethylxylopinine,...