Anti-malarial Activity of Isoquinoline Alkaloids from the Stem Bark of Actinodaphne macrophylla
Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values of 0.08 μM, 0.05 μM, 1.18 μM, 3.11 μM, 0.65 μM, 0.26 μM, and 1.38 μM for cycleanine, 10-demethylxylopinine,...
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| Main Authors: | , , , , |
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| Format: | Article PeerReviewed |
| Language: | English English English |
| Published: |
SAGE Publications Inc
2015
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/102679/1/C11-ARTIKEL.pdf https://repository.unair.ac.id/102679/3/C11-PEER%20REVIEW.pdf https://repository.unair.ac.id/102679/2/17%20%25%20Anti-malarial%20Activity%20of%20Isoquinoline%20Alkaloids%20from%20the%20Stem%20Bark%20of%20Actinodaphne%20macrophylla.pdf https://repository.unair.ac.id/102679/ https://journals.sagepub.com/doi/abs/10.1177/1934578X1501000913 https://doi.org/10.1177%2F1934578X1501000913 |
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| Institution: | Universitas Airlangga |
| Language: | English English English |
| Summary: | Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values of 0.08 μM, 0.05 μM, 1.18 μM, 3.11 μM, 0.65 μM, 0.26 μM, and 1.38 μM for cycleanine, 10-demethylxylopinine, reticuline, laurotetanine, bicuculine, α-hydrastine and anolobine, respectively, which are comparable with the reference standard, chloroquine. 10-Demethylxylopinine was found to be the most active of these compounds. |
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