#TITLE_ALTERNATIVE#
Abstract : <br /> <br /> <br /> <br /> Glybenclamide results in related substances under its degradation. Therefore for quality evaluation of glybenclamide bulk it needs such impurity references standard. To make a related substance, glybenclamide was refluxed in methanol...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/6888 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Abstract : <br />
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Glybenclamide results in related substances under its degradation. Therefore for quality evaluation of glybenclamide bulk it needs such impurity references standard. To make a related substance, glybenclamide was refluxed in methanol for 24 hours. The result of reflux was isolated and purificated by coloumn chromatography. The isolate was characterizated by thin-layer chromatography, ultraviolet light and infrared spectrophotometry. The isolate showed a different TLC profile and infrared spectrum to that of glybenclamide. The isolate was predicted to be a methyl N-4-[2-(5-chloro-2-methoxybenzamido)ethyl] benzenesulphonylcarbamat. <br />
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