CONSTRUCTION OF LEVOFLOXACIN-CITRIC ACID SALTS AND THE IMPACT TOWARD ITS CHEMICAL STABILITY
Levofloxacin (LF) is a wide-spectrum fluoroquinolone antibiotic. Based on references, it has poor stability because it degrades easily due to light and moisture. To improve the stability, solid materials engineering was conducted by organic salt composing. This research dealt with the composition...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/69273 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Levofloxacin (LF) is a wide-spectrum fluoroquinolone antibiotic. Based on references,
it has poor stability because it degrades easily due to light and moisture. To improve
the stability, solid materials engineering was conducted by organic salt composing.
This research dealt with the composition, structure determination, stability, and
antibiotic potency of a novel organic salt composed of levofloxacin (LF) and citric acid
(CA), named levofloxacin-citrate (LC). On the other hand, CA is a carboxylic group
acted as an antioxidant. Screening by binary phase diagram forming is done to
determine the stoichiometric composition of LF and CA, continued by react LF and CA
using slow (SE) and fast evaporation (FE) methods. A series of characterizations using
electrothermal, differential scanning calorimetry (DSC), powder X-ray diffractometry
(PXRD), Fourier Transform Infrared (FTIR), and proton nuclear magnetic resonance
(H-NMR) confirmed LC formation. The new organic salt showed a distinct thermogram
and diffractogram. Next, Fourier transform infrared indicated the change in Nmethylamine and carboxylic stretching, confirmed by
1
H nuclear magnetic resonance
spectra to elucidate the 2D structure. Finally, single-crystal diffractometry (SCXRD)
determined LC as a new salt structure three-dimensionally. The attributive
improvements were demonstrated on the stability toward the humidity and lighting of
LC compared to LF alone. Hereafter, LC is a potential salt antibiotic-antioxidant
combination for dosage formulas development.
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