CONSTRUCTION OF LEVOFLOXACIN-CITRIC ACID SALTS AND THE IMPACT TOWARD ITS CHEMICAL STABILITY

• Main Author: Namira Laksana, Agnesya
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/69273
• Institution: Institut Teknologi Bandung

Levofloxacin (LF) is a wide-spectrum fluoroquinolone antibiotic. Based on references, it has poor stability because it degrades easily due to light and moisture. To improve the stability, solid materials engineering was conducted by organic salt composing. This research dealt with the composition, structure determination, stability, and antibiotic potency of a novel organic salt composed of levofloxacin (LF) and citric acid (CA), named levofloxacin-citrate (LC). On the other hand, CA is a carboxylic group acted as an antioxidant. Screening by binary phase diagram forming is done to determine the stoichiometric composition of LF and CA, continued by react LF and CA using slow (SE) and fast evaporation (FE) methods. A series of characterizations using electrothermal, differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), Fourier Transform Infrared (FTIR), and proton nuclear magnetic resonance (H-NMR) confirmed LC formation. The new organic salt showed a distinct thermogram and diffractogram. Next, Fourier transform infrared indicated the change in Nmethylamine and carboxylic stretching, confirmed by 1 H nuclear magnetic resonance spectra to elucidate the 2D structure. Finally, single-crystal diffractometry (SCXRD) determined LC as a new salt structure three-dimensionally. The attributive improvements were demonstrated on the stability toward the humidity and lighting of LC compared to LF alone. Hereafter, LC is a potential salt antibiotic-antioxidant combination for dosage formulas development.