STUDY OF DRUG INTERACTIONS IN PATIENTS WITH POSITIVE SARS-COV-2 IN A HOSPITAL IN SUMEDANG
The treatment of SARS-CoV-2 continues to develop by involving various types of off-label drugs and various symptomatic or supportive therapeutic drugs. The use of these various types of drugs puts patients at risk for drug interactions. This study aims to analyze the potential interactions betwee...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/69412 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | The treatment of SARS-CoV-2 continues to develop by involving various types of
off-label drugs and various symptomatic or supportive therapeutic drugs. The use
of these various types of drugs puts patients at risk for drug interactions. This study
aims to analyze the potential interactions between drugs that can occur in
hospitalized SARS-CoV-2 patients and the factors that influence it. The study was
conducted with a cross-sectional design using a sample of hospitalized patients at a
Hospital in Sumedang. Analysis of potential interactions between drugs was carried
out using Micromedex®. The results of the study were 344 study samples and 312
had the potential for drug interactions, the majority of which were of moderate
severity (73%), with the most potential interactions greater than 5 (42.64%), and
the mechanism of pharmacodynamic interactions. The potential interactions found
were QT interval prolongation and decreased effectiveness. There is a positive
correlation between potential drug interactions with the number of drugs per
patient's drug card (r = 0.564), and length of hospitalization (r = 0.222).
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