SECONDARY METABOLITES OF LINDERA BIBRACTEATA BI. ( LAURACEAE)
Lauraceae is a family of plant which consists of 31 genera and 3000 species. About 600 species of this family grow in Indonesia. Eighteen genera of this family, including Lindera, are known to have high alkaloid contents, particularly aporphine type. One of the species of Lindera growing in Indon...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/72924 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Lauraceae is a family of plant which consists of 31 genera and 3000 species. About
600 species of this family grow in Indonesia. Eighteen genera of this family,
including Lindera, are known to have high alkaloid contents, particularly aporphine
type. One of the species of Lindera growing in Indonesian tropical rainforests is
Lindera bibracteata Bl. The secondary metabolites of this species is not well studied.
In this research, the isolation of the secondary metabolites of L. bibracteata stem
bark and their cytoxicity assay were conducted. By using extraction and various
chromatography methods, ten secondary metabolites of L. bibracteata have been
isolated. Based on the UV, 1H and 13C NMR spectroscopy, and mass spectroscopy
data, five of them were identified as N-methylnandigerine, nandigerine, launobine,
epicatechin, and ????-sitosterol. The IC50 value of N-methylnandigerine and nandigerine
against OVCAR-3 (human ovarian carcinoma cell-line 3) cells were 200 ????g/mL and
>500 ????g/mL, respectively. Both compounds have low activities compared to taxol
(IC50 17 ng/mL). However, it can be suggested that the N-methyl group has an
important role to increase the cytotoxicity of aporphine alkaloids against OVCAR-3
cells. |
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