LUBRICATION AND COMPRESSION PROCESS PARAMETERS OPTIMIZATION OF VITAMIN C TABLET

• Main Author: Arianditha Pranasti, Ernestine
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/75694
• Institution: Institut Teknologi Bandung

The production of tablets is a very intricate process that is influenced by numerous process variables or parameters. The objective of this work was to identify, using a statistical experimental design, the critical processing variables that affect Critical Quality Attributes (CQAs) Vitamin C film-coated caplets. A two-level complete factorial design with two central points was used to examine the process parameters that posed the greatest risk to CQA. The process variables investigated were mesh number, lubrication time, compression process speed and main thickness. Statistical results showed that mesh number, lubrication duration, and their interaction have significant effects on flow rate, Hausner Ratio, and compressibility index. Higher mesh number and longer duration resulted in better flow properties. Main thickness parameter has significant effect on core caplet hardness, thinner main thickness will increase caplet hardness. The compression speed parameter has a significant effect on product dissolution, low product dissolution observed due to higher speed compression. Based on this study, it can be concluded that mesh number and lubrication duration only have a significant impact on the bulk quality attributes, but do not have a significant impact on the Vitamin C caplets quality attributes, while the compression process parameters (speed and main thickness) have a significant effect on Vitamin C caplets quality attributes. Mesh number 20 with a lubrication time of 7 minutes, 17 rpm speed with a major thickness scale of 2.00 are estimated to be the best parameter processes for producing optimum CQA Vitamin C caplet.