FORMULATION AND CHARACTERIZATION OF LIQUID CRYSTAL CREAM WITH ALPHA-TOCOPHERYL ACETATE AND OLIVE OIL (OLEA EUROPAEA L.), AND EVALUATION OF CREAM STABILITY

• Main Author: Meilyna, Sherleen
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/76597
• Institution: Institut Teknologi Bandung

Alpha-tocopherol acetate and olive oil are antioxidants that can overcome premature aging due to free radicals. Alpha-tocopherol acetate and olive oil were formulated into liquid crystal cream preparations with a lamellar structure. Since the lamellar structure resembles the physiological structure of the skin, it can increase hydration in the skin. The purpose of this study was to determine the optimum formula of liquid crystal cream with a lamellar structure, characterize the physical and chemical properties of the cream, and evaluate the level of alpha-tocopherol acetate and antioxidant activity of the preparations. The optimum formula of liquid crystal cream contains tocopherol acetate 0.5% (w/w), olive oil 5% (w/w), ceteareth-25 1.25% (w/w), cetyl alcohol 3.75% (w/w) with a ratio of 1:3 (Ceteareth-25:cetyl alcohol), propylene glycol 5% (w/w), glycerin 5% (w/w), phenoxyethanol 0.5% (w/w), has a lamellar liquid crystal structure with a globular size of 3.28 ± 0.46 ?m, stable after centrifuge and freeze-thaw, pH 6.97 ± 0.08, viscosity 8910 ± 256.32 cP, dispersion 16.06 ± 2.30 g.cm/s, occlusion properties 44.81 ± 3.31%, has alpha-tocopherol acetate levels of 93.13 ± 1.50% in the preparation. The optimum formula of liquid crystal cream has a stable viscosity at storage temperatures of 4°C for 28 days.