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ABSTRACT: <br /> <br /> <br /> Diffusion of Propranolol hydrochloride from gel prepared by using hydroxipropyl cellulose in various ratio of ethanol-water as gel base with and without addition of penetration enhancer, followed by irritation test on rabbit skin had been studied. Re...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/7666 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | ABSTRACT: <br />
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Diffusion of Propranolol hydrochloride from gel prepared by using hydroxipropyl cellulose in various ratio of ethanol-water as gel base with and without addition of penetration enhancer, followed by irritation test on rabbit skin had been studied. Result showed that diffused propranolol hydrochloride from gel containing 5% Tween 20 was more than that from gel without penetration enhancer, and the gel did not irritate rabbit skin. Diffusion test was performed in vitro by using impregned Whatman paper No.1 with Spangler solution. Penetration enhancer was used such as propylen-glycol, aceton, menthol, dimethylsulphoxide (DMSO), Tween 20, and Tween 60. |
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