PRELIMINARY STUDY OF FABRICATING D-SHAPED POLYMER OPTICAL FIBER (POF) SENSOR WITH GOLD FILM TIPIS DEPOSITION FOR SURFACE PLASMON RESONANCE (SPR)-BASED BIOCHEMICAL APPLICATIONS: TESTING WITH GLYCERIN
Surface Plasmon Resonance (SPR)-based sensing has gained increasing popularity in various biochemical applications, especially for detecting biomolecular interactions due to its capability for real-time detection and proven high sensitivity for label-free detection of biomolecules. Consequently,...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/78315 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Surface Plasmon Resonance (SPR)-based sensing has gained increasing popularity
in various biochemical applications, especially for detecting biomolecular
interactions due to its capability for real-time detection and proven high sensitivity
for label-free detection of biomolecules. Consequently, there is a growing demand
for the development of SPR sensor technology for rapid testing at point-of-care.
However, commercialized SPR sensors are not unfitting to enable rapid testing at
point of care due to their large size, lack of portability, and high cost.
On the other hand, fiber optic-based SPR sensing offers the potential for compact
and portable SPR devices, well-suited for easy, fast, and cost-effective point-of-care
testing. In this final project research, the author has conducted an experiment as a
preliminary study to develop an SPR sensor using polymer optical fiber (POF) and
optimization of fabrication techniques and thin gold film thickness deposition was
conducted to characterize the optical parameters of the POF-based SPR sensor in
response to changes in the refractive index using varying concentrations of glycerin
solutions.
From a range of POF-based SPR sensors variation, the best-performing sensor
achieving a sensitivity value of 4,585 ± 0,489 within R-squared coefficient 0,936, a
Limit of Detection (LoD) of 0.31 mM, stability of 63,5%, and a penetration depth
of 77.7 nm. These results demonstrate that the fabricated POF-based SPR sensor
can generate surface plasmon resonance and deliver a robust SPR response in
detecting changes in glycerin concentration within the sensing element with a D-
shaped geometry. This research paves the way for the development of compact and
portable SPR sensors suitable for point-of-care applications. |
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