EFFECT OF SALT TRANSFORMATION ON DISSOLUTION OF METOCLOPRAMIDE TABLETS

• Main Author: Armand Muntaka, Rifazt
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/78387
• Institution: Institut Teknologi Bandung

Metoclopramide (MCP) is an antiemetic dopamine D2 antagonist to relieve nausea and vomiting by increasing gastric motility. MCP in basic form has potential to be modified into multicomponent crystal because of the presence of hydrogen bond donor and acceptor. In previous study, multicomponent crystal from MCP base has been made with gallic acid (GAL) and oxalic acid (OXA) as coformers. MCP-GAL showed higher intrinsic dissolution and solubility than MCP. The study will be continued with the manufacture of MCP and MCP-GAL into tablets with wet granulation and direct compression, then the dissolution is compared to see the effect of turning MCP into salt on the dissolution of MCP tablets. MCP-GAL for this study was prepared with slurry method. The formation of MCP-GAL was confirmed with DSC and PXRD. MCP-GAL is confirmed to be formed because DSC shows new melting point peak (211,87oC) and PXRD shows different peak than then forming materials. This is followed by making MCP and MCP-GAL wet granulation and direct compression tablet each with the same formula. Granule of MCP and MCP-GAL are evaluated for Hausner ratio and compressibility index to see flowability. Tablet of MCP and MCP-GAL are evaluated for tablet hardness, disintegration time, and dissolution profile. MCP-GAL wet granulation tablet showed 3,1 times higher dissolution than MCP and MCP-GAL direct compression tablet showed 3,55 times higher dissolution than MCP. Formation of salt is proven to be ablet to increase dissolution of MCP tablet.