SIMULTANEOUS COCRYSTALLIZATION AND MICRONIZATION OF PARACETAMOL-DIPICOLINIC ACID BY SUPERCRITICAL ANTISOLVENT (SAS)

• 主要作者: Hiendrawan, Stevanus
• 格式: Theses
• 語言: Indonesia
• 在線閱讀: https://digilib.itb.ac.id/gdl/view/78630
• 機構: Institut Teknologi Bandung

Paracetamol (PCA) is the widely used analgesic and antipyretic drug. In the market, PCA exist as polymorph form I which have poor tabletability. The aim of this study was to improve the tabletability of PCA by using cocrystallization method with dipicolinic acid (DPA) and to evaluate the influence o...