ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR TESTING DISSOLUTION OF DIGOXIN TABLET USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

• المؤلف الرئيسي: Maryati, Leni
• التنسيق: Theses
• اللغة: Indonesia
• الوصول للمادة أونلاين: https://digilib.itb.ac.id/gdl/view/78772

Digoxin is commonly used to treat heart failure. Digoxin is drug with a narrow therapeutic window. According to the Indonesian Pharmacopoeia IV, digoxin tablets dissolution was tested in 0.1 N HCI medium using fluorometric method. In this dissolution medium, digoxin could be hydrolyzed into compound...