FORMULATION DEVELOPMENT AND IN VITRO PENETRATION TEST OF MEFENAMIC ACID NANOEMULGEL THROUGH TOPICAL DELIVERY
Mefenamic acid is a nonsteroidal antiinflammatory drug that has several drawbacks, namely causing epigastric and abdominal pain when consumed orally, and exhibiting poor water solubility characteristics. This research was conducted to address these drawbacks by developing a topical nanoemulgel...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/80371 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Mefenamic acid is a nonsteroidal antiinflammatory drug that has several drawbacks, namely
causing epigastric and abdominal pain when consumed orally, and exhibiting poor water solubility
characteristics. This research was conducted to address these drawbacks by developing a topical
nanoemulgel formulation of mefenamic acid. The development of the mefenamic acid nanoemulgel
was carried out through the optimization of mefenamic acid nanoemulsion formula,
characterization of the nanoemulsion, evaluation of nanoemulsion stability, optimization of the gel
base in the nanoemulgel, characterization of the nanoemulgel, and in vitro penetration evaluation.
The optimum formula for mefenamic acid nanoemulsion consists of caprylic/capric triglyceride oil
10%, mefenamic acid 1%, tween 60-PEG 400 (1:1) with a total concentration of 15%, methyl
paraben 0.18%, propyl paraben 0.02%, propylene glycol 5%, dan aquadest 68.8%. The mefenamic
acid nanoemulsion has a milky white appearance with a droplet size of 140.03±3.53 nm, PDI of
0.28±0.09, zeta potential of -31.20±2.87 mV, pH of 4.81±0.01, and mefenamic acid content of
98.11±1.00%. Stability evaluation results show that the mefenamic acid nanoemulsion begins to
seperate when centrifuged. However, the nanoemulsion remains stable after 3 freeze-thaw cycles.
Additionally, stability evaluation through 28 days of storage indicates that the mefenamic acid
nanoemulsion is stable at a storage temperature of 4oC, but starts to increase in droplet diameter
and decrease in pH when stored at temperatures of 25oC and 40oC. The optimum gel base for the
mefenamic acid nanoemulgel is carbopol 940 1%. The resulting mefenamic acid nanoemulgel has a
viscosity of 185.78±6.62 P, pH of 6.16±0.08, and mefenamic acid content of 97.49±1.06%. In vitro
penetration testing of the mefenamic acid nanoemulgel shows a release of 57.14±0.57% over 24
hours, with release kinetics following zero-order kinetics.
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