SYNTHESIS OF FAVIPIRAVIR AND ITS DERIVATIVES FROM 3-HYDROXYPIRAZINE-2-CARBOXAMIDE
Favipiravir is a compound that appear to be one of pyrazine analogue that can act as Active Pharmaceutical Ingredients (API) and have been used as antiviral caused by Zika virus, Ebola virus, including SARS-CoV-2. The demand of favipiravir demand has been increased due to high cases of SARS-Co...
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| Format: | Final Project |
| Language: | Indonesia |
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| Online Access: | https://digilib.itb.ac.id/gdl/view/82860 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Favipiravir is a compound that appear to be one of pyrazine analogue that can act as Active
Pharmaceutical Ingredients (API) and have been used as antiviral caused by Zika virus, Ebola
virus, including SARS-CoV-2. The demand of favipiravir demand has been increased due to
high cases of SARS-CoV-2 epidemic spread. Favipiravir play a big role as RNA-dependent
RNA polymerase (RdRp) inhibitor which impactful by obstruct the growth of new virus.
Various synthesis methods and routes have been developed with changes in stages, precursors,
and conditions to determine the optimum condition of favipiravir synthesis method. In this
experiment, optimization was conducted by deduct the reaction stages to one step, which is
the fluorination of 3-hydroxypyrazine-2-carboxamide using Selectfluor®. Various reaction
conditions were also varied to obtain conditions that could yield the optimum product yield.
Thus, the favipiravir synthesis method can be carried out by reducing energy requirements,
waste production, time, and being more economical. Synthesis of favipiravir derivative
compounds is also carried out to improve modification of pyrazine widely developed as drugs,
so structural analysis and effectiveness of new pyrazine compounds need to be conducted. The
synthesized compound will then be characterized using 1H-NMR and 13C-NMR as well as 2D
NMR. The yield value of the optimized synthesis of favipiravir compounds is determined by
High Pressure Liquid Chromatography (HPLC) yield method and the highest HPLC yield
value obtained is 23.41% out of 18 variations of reaction condition. In this research, five (5)
favipiravir derivative that substituted at C-6 resulting in ether groups have been produced,
which consist of one new compound and four compounds that previously have been reported |
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