SYNTHESIS OF FAVIPIRAVIR AND ITS DERIVATIVES FROM 3-HYDROXYPIRAZINE-2-CARBOXAMIDE

• Main Author: Lokitha, Angela
• Format: Final Project
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/82860
• Institution: Institut Teknologi Bandung

Favipiravir is a compound that appear to be one of pyrazine analogue that can act as Active Pharmaceutical Ingredients (API) and have been used as antiviral caused by Zika virus, Ebola virus, including SARS-CoV-2. The demand of favipiravir demand has been increased due to high cases of SARS-CoV-2 epidemic spread. Favipiravir play a big role as RNA-dependent RNA polymerase (RdRp) inhibitor which impactful by obstruct the growth of new virus. Various synthesis methods and routes have been developed with changes in stages, precursors, and conditions to determine the optimum condition of favipiravir synthesis method. In this experiment, optimization was conducted by deduct the reaction stages to one step, which is the fluorination of 3-hydroxypyrazine-2-carboxamide using Selectfluor®. Various reaction conditions were also varied to obtain conditions that could yield the optimum product yield. Thus, the favipiravir synthesis method can be carried out by reducing energy requirements, waste production, time, and being more economical. Synthesis of favipiravir derivative compounds is also carried out to improve modification of pyrazine widely developed as drugs, so structural analysis and effectiveness of new pyrazine compounds need to be conducted. The synthesized compound will then be characterized using 1H-NMR and 13C-NMR as well as 2D NMR. The yield value of the optimized synthesis of favipiravir compounds is determined by High Pressure Liquid Chromatography (HPLC) yield method and the highest HPLC yield value obtained is 23.41% out of 18 variations of reaction condition. In this research, five (5) favipiravir derivative that substituted at C-6 resulting in ether groups have been produced, which consist of one new compound and four compounds that previously have been reported