#TITLE_ALTERNATIVE#

• Main Author: H. Sutrisno, Lestiani
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/8464
• Institution: Institut Teknologi Bandung

Abstract: <br /> <br /> <br /> The local anaesthetic effect of lidocaine-epinephrine preparations administered by iontophoresis has been studied on rabbits. <br /> <br /> <br /> The evaluation of the anaesthetic effect was done by the prick test and by intermittent electric current test. A strong relation between the two methods was found (the corelation factor of each treatment is between 0,84-0,99). <br /> <br /> <br /> A comparison between two products (factory made and the other one prepared in the laboratory) with the same concentration of lidocaine and different salts of epinephrine resulted in a meaningful difference of anesthesia (P<0,05), the one prepared in the laboratory having the greater effect. <br /> <br /> <br /> The effect of local anaesthesia produce by subcutan injection was much greater (more than three hours) compare to the one produce by iontophoresis (less than one hour). <br /> <br /> <br /> Among the various lidocaine-epinephrine preparations studied in this experiment for their local anaesthetic effect, the greatest effect was observed with the preparation containing lidocaine HCl 2% and epinephrine bitartrat 1:80.000.