ANTI-INFLAMMATORY POTENTIAL OF BLACK SOLDIER FLY (HERMETIA ILLUCENS L.) LARVA OIL

• Main Author: Devi Amadea, Raissa
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/85411
• Institution: Institut Teknologi Bandung

Inflammation is the immune system's response to a pathogen, tissue injury, and infection in body cells which can cause symptoms like redness (rubor/erythema), swelling (tumor/edema), fever (calor), pain (dolor), and loss of organ/tissue function. Natural medicine can be an alternative therapy that is considered to have low side effects and safer to consume if used properly. One of natural ingredient that has potential to treat inflammation is Black Soldier Fly larvae (Hermetia illucens L.). This study aims to determine the anti-inflammatory activity of Black Soldier Fly / BSF (Hermetia illucens L.) larvae oil in vitro. The BSF larvae oil obtained from the extraction process using the reflux method with n-hexane solvent was tested for its anti-inflammatory activity using inhibition protein denaturation method and blood membrane stabilization using sodium diclofenac as a standard. The extract with the best anti-inflammatory activity was shown by BSF D15 larva extract with an IC50 value of 303,100 ± 44,481 µg/mL in the protein denaturation test and 6720,137 ± 83,700 µg/mL in the blood membrane stabilization test. Further characterization and identification are needed in development of anti-inflammatory preparations based on BSF larvae extract.