#TITLE_ALTERNATIVE#
Abstract : <br /> <br /> <br /> The in-vitro and in-vivo effect of penetration enhancers 10% ethanol, 2 and 5% dimethyl sulfoxide, 5 and 10% ethyl acetate, a mixture of 5% ethanol and 10% ethyl acetate on transdermal absorption of diclofenac diethylammonium in hydroxypropyl methyl...
Saved in:
| Main Author: | |
|---|---|
| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/9002 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| id |
id-itb.:9002 |
|---|---|
| spelling |
id-itb.:90022017-09-27T15:32:13Z#TITLE_ALTERNATIVE# Nofita Rahman (NIM 207 92 008), Rahmi Indonesia Theses INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/9002 Abstract : <br /> <br /> <br /> The in-vitro and in-vivo effect of penetration enhancers 10% ethanol, 2 and 5% dimethyl sulfoxide, 5 and 10% ethyl acetate, a mixture of 5% ethanol and 10% ethyl acetate on transdermal absorption of diclofenac diethylammonium in hydroxypropyl methylcellulose aqueous gel had been studied. The in-vitro penetration was determined using diffusion cell with Spangler fluid impregnated Whatman paper no. 1 and a phosphate buffer of pH 7,4 as reseptor medium. Quantitation of diclofenac diethylammonium in the receptor medium was done using ultraviolet-visible spectrophotometry. The in-vivo penetration study was carried out using patch test on six New Zealand strain rabbits. Serum diclofenac level was determined by high performance liquid chromatography. The result showed that 10% ethyl acetate enhanced the transdermal diclofenac diethylammonium absorption. text |
| institution |
Institut Teknologi Bandung |
| building |
Institut Teknologi Bandung Library |
| continent |
Asia |
| country |
Indonesia Indonesia |
| content_provider |
Institut Teknologi Bandung |
| collection |
Digital ITB |
| language |
Indonesia |
| description |
Abstract : <br />
<br />
<br />
The in-vitro and in-vivo effect of penetration enhancers 10% ethanol, 2 and 5% dimethyl sulfoxide, 5 and 10% ethyl acetate, a mixture of 5% ethanol and 10% ethyl acetate on transdermal absorption of diclofenac diethylammonium in hydroxypropyl methylcellulose aqueous gel had been studied. The in-vitro penetration was determined using diffusion cell with Spangler fluid impregnated Whatman paper no. 1 and a phosphate buffer of pH 7,4 as reseptor medium. Quantitation of diclofenac diethylammonium in the receptor medium was done using ultraviolet-visible spectrophotometry. The in-vivo penetration study was carried out using patch test on six New Zealand strain rabbits. Serum diclofenac level was determined by high performance liquid chromatography. The result showed that 10% ethyl acetate enhanced the transdermal diclofenac diethylammonium absorption. |
| format |
Theses |
| author |
Nofita Rahman (NIM 207 92 008), Rahmi |
| spellingShingle |
Nofita Rahman (NIM 207 92 008), Rahmi #TITLE_ALTERNATIVE# |
| author_facet |
Nofita Rahman (NIM 207 92 008), Rahmi |
| author_sort |
Nofita Rahman (NIM 207 92 008), Rahmi |
| title |
#TITLE_ALTERNATIVE# |
| title_short |
#TITLE_ALTERNATIVE# |
| title_full |
#TITLE_ALTERNATIVE# |
| title_fullStr |
#TITLE_ALTERNATIVE# |
| title_full_unstemmed |
#TITLE_ALTERNATIVE# |
| title_sort |
#title_alternative# |
| url |
https://digilib.itb.ac.id/gdl/view/9002 |
| _version_ |
1820664566543024128 |