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Several studies have shown central nervous stimulant/antidepressant effect of Myristica fragrans Houtt. mace (MM). This study was carried out to examine stimulant effect of fractions of MM ethanolic extract. Ethanolic extract of MM were consecutively fractionated with nhexane and ethyl acetate. Each...

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Main Author: CHAIRUL LATIEF , AKHMAD
Format: Final Project
Language:Indonesia
Subjects:
Farmakologi dan terapeutik
Online Access:https://digilib.itb.ac.id/gdl/view/9855
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Institution: Institut Teknologi Bandung
Language: Indonesia
id id-itb.:9855
spelling id-itb.:98552009-04-15T18:35:31Z#TITLE_ALTERNATIVE# CHAIRUL LATIEF , AKHMAD Farmakologi dan terapeutik Indonesia Final Project INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/9855 Several studies have shown central nervous stimulant/antidepressant effect of Myristica fragrans Houtt. mace (MM). This study was carried out to examine stimulant effect of fractions of MM ethanolic extract. Ethanolic extract of MM were consecutively fractionated with nhexane and ethyl acetate. Each fraction at doses of 10100 mg/kg bw was administered to different group of mice. Five minutes later, the mice behaviors were examined in openfield apparatus for 15 minutes. The stimulated mice were sacrificed, and the levels of astrocytes in the cerebral cortex and caudate putamen were examined. Rearing time and total distance travelled were increased significantly (P <0,05) after administration of ethyl acetate fraction at 60 mg/kg dan 15 mg/kg bw caffeine. Drug treatment also resulted in increased levels of astrocytes in the motor centre M1 and M2. The results suggested that ethyl acetate fraction of ethanolic extract of Myristica fragrans mace has CNS stimulating activity. <br /> <br /> text
institution Institut Teknologi Bandung
building Institut Teknologi Bandung Library
continent Asia
country Indonesia
Indonesia
content_provider Institut Teknologi Bandung
collection Digital ITB
language Indonesia
topic Farmakologi dan terapeutik
spellingShingle Farmakologi dan terapeutik
CHAIRUL LATIEF , AKHMAD
#TITLE_ALTERNATIVE#
description Several studies have shown central nervous stimulant/antidepressant effect of Myristica fragrans Houtt. mace (MM). This study was carried out to examine stimulant effect of fractions of MM ethanolic extract. Ethanolic extract of MM were consecutively fractionated with nhexane and ethyl acetate. Each fraction at doses of 10100 mg/kg bw was administered to different group of mice. Five minutes later, the mice behaviors were examined in openfield apparatus for 15 minutes. The stimulated mice were sacrificed, and the levels of astrocytes in the cerebral cortex and caudate putamen were examined. Rearing time and total distance travelled were increased significantly (P <0,05) after administration of ethyl acetate fraction at 60 mg/kg dan 15 mg/kg bw caffeine. Drug treatment also resulted in increased levels of astrocytes in the motor centre M1 and M2. The results suggested that ethyl acetate fraction of ethanolic extract of Myristica fragrans mace has CNS stimulating activity. <br /> <br />
format Final Project
author CHAIRUL LATIEF , AKHMAD
author_facet CHAIRUL LATIEF , AKHMAD
author_sort CHAIRUL LATIEF , AKHMAD
title #TITLE_ALTERNATIVE#
title_short #TITLE_ALTERNATIVE#
title_full #TITLE_ALTERNATIVE#
title_fullStr #TITLE_ALTERNATIVE#
title_full_unstemmed #TITLE_ALTERNATIVE#
title_sort #title_alternative#
url https://digilib.itb.ac.id/gdl/view/9855
_version_ 1820664814634008576

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