Expression of Melan-A in Depigmented Skin of Vitiligo Patients
Background: Vitiligo is an acquired and commonly found pigmentation disorder characterized by milky-white patches on the skin, hair, and mucosa due to melanocyte damage. The cause of vitiligo is still unclear. A study proves that cell-mediated immunity plays a role in the pathogenesis of vitiligo. M...
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| Main Authors: | , , |
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| Format: | Article PeerReviewed |
| Language: | English English English |
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Fakultas Kedokteran Universitas Airlangga
2020
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| Online Access: | http://repository.unair.ac.id/105472/1/Expression%20of%20Melan-A%20in%20Depigmented%20skin%20of%20Vitiligo%20Patients.pdf http://repository.unair.ac.id/105472/2/Expression%20of%20Melan-A.pdf http://repository.unair.ac.id/105472/3/Expression%20of%20Melan-A%20in%20Depigmented%20skin%20of%20Vitiligo%20Patients.pdf http://repository.unair.ac.id/105472/ https://e-journal.unair.ac.id/BIKK/article/view/12481 http://dx.doi.org/10.20473/bikk.V32.1.2020.17-20 |
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| Institution: | Universitas Airlangga |
| Language: | English English English |
| Summary: | Background: Vitiligo is an acquired and commonly found pigmentation disorder characterized by milky-white patches on the skin, hair, and mucosa due to melanocyte damage. The cause of vitiligo is still unclear. A study proves that cell-mediated immunity plays a role in the pathogenesis of vitiligo. Melan-A is a melanoma-related antigen that is recognized by autologous cytotoxic T cells and one of the critical markers for detecting melanocytes. Objective: To evaluate the expression of Melan-A in depigmented lesions of vitiligo patients. Methods: A descriptive study aimed to describe the expression of Melan-A in the depigmented skin of vitiligo patients at the Dermatovenerology Outpatient Clinic Cosmetic Division of Academic General Hospital Dr. Soetomo Surabaya. Eleven study subjects were selected through a sequence of selection. Results: Melan-A expression in the depigmented skin of vitiligo patients was lower than the average. This result was found in 6 (54.55%) out of 11 patients. Conclusion: Melan-A expressions on depigmented skins of vitiligo patients are generally below the average value; therefore, adequate intervention is needed to increase the Melan-A expression. |
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