Expression of Melan-A in Depigmented Skin of Vitiligo Patients

• Main Authors: Tjokorde Istri Nindya Vaniary, Muhammad Yulianto Listiawan, Dwi Murtiastutik
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Fakultas Kedokteran Universitas Airlangga 2020
• Subjects: R Medicine (General); RL Dermatology
• Online Access: http://repository.unair.ac.id/105472/1/Expression%20of%20Melan-A%20in%20Depigmented%20skin%20of%20Vitiligo%20Patients.pdf; http://repository.unair.ac.id/105472/2/Expression%20of%20Melan-A.pdf; http://repository.unair.ac.id/105472/3/Expression%20of%20Melan-A%20in%20Depigmented%20skin%20of%20Vitiligo%20Patients.pdf; http://repository.unair.ac.id/105472/; https://e-journal.unair.ac.id/BIKK/article/view/12481; http://dx.doi.org/10.20473/bikk.V32.1.2020.17-20
• Institution: Universitas Airlangga

Background: Vitiligo is an acquired and commonly found pigmentation disorder characterized by milky-white patches on the skin, hair, and mucosa due to melanocyte damage. The cause of vitiligo is still unclear. A study proves that cell-mediated immunity plays a role in the pathogenesis of vitiligo. Melan-A is a melanoma-related antigen that is recognized by autologous cytotoxic T cells and one of the critical markers for detecting melanocytes. Objective: To evaluate the expression of Melan-A in depigmented lesions of vitiligo patients. Methods: A descriptive study aimed to describe the expression of Melan-A in the depigmented skin of vitiligo patients at the Dermatovenerology Outpatient Clinic Cosmetic Division of Academic General Hospital Dr. Soetomo Surabaya. Eleven study subjects were selected through a sequence of selection. Results: Melan-A expression in the depigmented skin of vitiligo patients was lower than the average. This result was found in 6 (54.55%) out of 11 patients. Conclusion: Melan-A expressions on depigmented skins of vitiligo patients are generally below the average value; therefore, adequate intervention is needed to increase the Melan-A expression.