Two novel coumarins bearing an acetophenone derivative from the leaves of Melicope Quercifolia
Meliquercifolins A (1), and B (2), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of Melicope quercifolia along with three known compounds, melicodenines E (3), F (4) and I (5). Structures of two new compounds were identified based on spectroscopic analyses (U...
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| Main Authors: | , , |
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| Format: | Article PeerReviewed |
| Language: | English English English English |
| Published: |
Taylor & Francis
2021
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| Online Access: | http://repository.unair.ac.id/105808/1/C03.%20Fulltext_Two%20novel%20coumarins.pdf http://repository.unair.ac.id/105808/4/C03.%20Validasi%20dan%20Penilaian.pdf http://repository.unair.ac.id/105808/2/C03.%20Similarity_Two%20novel%20coumarins.pdf http://repository.unair.ac.id/105808/3/C03.%20Korespondensi.pdf http://repository.unair.ac.id/105808/ https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1644634 https://doi.org/10.1080/14786419.2019.1644634 |
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| Institution: | Universitas Airlangga |
| Language: | English English English English |
| Summary: | Meliquercifolins A (1), and B (2), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of Melicope quercifolia along with three known compounds, melicodenines E (3), F (4) and I (5). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D and 2 D NMR). Cytotoxic activities of compounds (1–5) towards three human cancer cells (HeLa, MCF-7, P-388), compounds 1, 4 and 5 showed very potent activity against Hela cells with IC50 values 2.6; 0.8; 1.1 μM, respectively. |
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