Two novel coumarins bearing an acetophenone derivative from the leaves of Melicope Quercifolia

• Main Authors: Ratih Dewi Saputri, Tjitjik Srie Tjahjandarie, Mulyadi Tanjung
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Taylor & Francis 2021
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://repository.unair.ac.id/105808/1/C03.%20Fulltext_Two%20novel%20coumarins.pdf; http://repository.unair.ac.id/105808/4/C03.%20Validasi%20dan%20Penilaian.pdf; http://repository.unair.ac.id/105808/2/C03.%20Similarity_Two%20novel%20coumarins.pdf; http://repository.unair.ac.id/105808/3/C03.%20Korespondensi.pdf; http://repository.unair.ac.id/105808/; https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1644634; https://doi.org/10.1080/14786419.2019.1644634
• Institution: Universitas Airlangga

Meliquercifolins A (1), and B (2), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of Melicope quercifolia along with three known compounds, melicodenines E (3), F (4) and I (5). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D and 2 D NMR). Cytotoxic activities of compounds (1–5) towards three human cancer cells (HeLa, MCF-7, P-388), compounds 1, 4 and 5 showed very potent activity against Hela cells with IC50 values 2.6; 0.8; 1.1 μM, respectively.