A New Cinnamyl Acid Derivative from the Roots of Willughbeia coriacea Wall

• Main Authors: Mulyadi Tanjung, Tjitjik Srie Tjahjandarie, Ratih Dewi Saputri, Andre Harsono, Muhammad Fajar Aldin
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Korean Society of Pharmacognosy 2020
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://repository.unair.ac.id/105810/3/C04.%20Fulltext_Willughbeia%20coriceae.pdf; http://repository.unair.ac.id/105810/4/C04.%20Validasi%20dan%20Penilaian.pdf; http://repository.unair.ac.id/105810/2/C04.%20Similarity_A%20New%20Cinnamyl%20Acid.pdf; http://repository.unair.ac.id/105810/1/C04.%20Korespondensi.pdf; http://repository.unair.ac.id/105810/; https://koreascience.or.kr/article/JAKO202010060596208.page; https://doi.org/10.20307/nps.2020.26.1.79
• Institution: Universitas Airlangga

A new cinnamyl acid derivative, willughbein A (1) along with pinoresinol (2), alyterinate A (3), and scopoletin (4), were isolated from the roots of Willughbeia coriacea Wall. The structure of 1 has been determined based on HRESIMS, 1D, and 2D NMR spectral data. All of the isolates were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D, MCF-7, and P-388). Compound 3 showed moderate activity against P-388 cells with an IC50 value of 3.04 ㎍/mL.