VLADINOL F, NEOLIGNAN COMPOUND FROM THE STEM BARK OF Dryobalanops oblongifolia (DIPTEROCARPACEAE) AND ANTIPLASMODIAL ACTIVITY

• Main Authors: Indriani, .-, N.S. Aminah*, .-, N.N. Tri Puspaningsih, .-, Y. Takaya, .-, P. Satrimafitrah, .-
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Rasayan Journal 2021
• Subjects: Q Science; QD Chemistry
• Online Access: http://repository.unair.ac.id/109930/2/C05.%20Fulltext_VLADINOL%20F_RASAYAN%20INDRI.pdf; http://repository.unair.ac.id/109930/4/C05.%20Review%20dan%20Validasi_VLADINOL%20F_RASAYAN%20INDRI.pdf; http://repository.unair.ac.id/109930/1/C05.%20Similarity_25_VLADINOL%20F_RASAYAN%20INDRI.pdf; http://repository.unair.ac.id/109930/3/C05.%20Bukti%20Komunikasi_VLADINOL%20F_RASAYAN%20INDRI.pdf; http://repository.unair.ac.id/109930/; http://rasayanjournal.co.in/admin/php/upload/3051_pdf.pdf; https://dx.doi.org/10.31788/%20RJC.2021.1416017
• Institution: Universitas Airlangga

Drybalanops oblongifolia known as kayu kapur is a plant member of Dipterocarpaceae family. A neolignan, vladinol F, was successfully isolated from the dissolved fraction in acetone-ether of Dryobalanops oblongifolia stem bark. The chemical structure's determination was done based on an analysis of UV-Vis, NMR, and MS spectra and a comparison with the reference. In vitro test of this compound against Plasmodium falciparum 3D7 showed that IC50 value was 3.51 μg/mL.