The effects of golden sea cucumber extract (Stichopus hermanii) on the number of lymphocytes during the healing process of traumatic ulcer on wistar rat’s oral mucous
Background: Indonesia is a country with the world’s biggest potential and producer of sea cucumbers. Golden sea cucumber contains glicosaminoglycans, such as heparan sulphate and chondroitin sulphate, which could have a positive implication on wound healing process. This acceleration of wound heali...
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Main Authors: | , , , , |
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Format: | Article PeerReviewed |
Language: | Indonesian Indonesian Indonesian Indonesian |
Published: |
Fakultas Kedokteran Gigi Universitas Airlangga
2015
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Subjects: | |
Online Access: | https://repository.unair.ac.id/111023/1/the%20effects%20of%20golden%20sea%20cucumber%20extract.pdf https://repository.unair.ac.id/111023/3/22.The%20effects%20of%20golden%20sea%20cucumber%20extract%20%28Stichopus%20hermanii%29%20%282%29.pdf https://repository.unair.ac.id/111023/2/22.%20Pratiwi%20%28%20The%20Effects%20of%20Golden%20Sea%29%2022.pdf https://repository.unair.ac.id/111023/6/28.Dr.Pratiwi%20%28The%20Effects%20of%20Golden%20sea%20...%29.pdf https://repository.unair.ac.id/111023/ |
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Institution: | Universitas Airlangga |
Language: | Indonesian Indonesian Indonesian Indonesian |
Summary: | Background: Indonesia is a country with the world’s biggest potential and producer of sea cucumbers. Golden sea cucumber
contains glicosaminoglycans, such as heparan sulphate and chondroitin sulphate, which could have a positive implication on wound healing process. This acceleration of wound healing process could be observed through the increasing of lymphocytes on ulcus traumaticus. Purpose: This study aims to analyze the effects of golden sea cucumber extract on the number of lymphocytes during the
healing process of traumatic ulcer on Wistar rat’s oral mucous. Method: Golden sea cucumber extrat was made with freeze-dried method, and then gel was prepared using PEG 400 and PEG 4000 solvent. Twenty male rats with mucosal ulcus made were divided into a control group and three treatment groups with 20%, 40% and 80% golden sea cucumber extracts. All samples were euthanized on day 4 and then a preparation for histopathological examination was made to examine the number of lymphocytes. Result: The biggest number of lymphocytes was found in the treatment group with 40% golden sea cucumber extract, while the lowest one was found in the control group. The results of one way Anova test then showed a significant difference between the control group and the
treatment groups. And, the results of Tukey HSD showed a significant difference between the control group and the treatment group with 40% golden sea cucumber extract. Conclusion: It can be concluded that 40% golden sea cucumber (Stichopus hermanii) extract can increase the number of lymphocytes during the healing process of traumatic ulcer on Wistar rat’s oral mucous. |
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