The effects of golden sea cucumber extract (Stichopus hermanii) on the number of lymphocytes during the healing process of traumatic ulcer on wistar rat’s oral mucous

• Main Authors: Ira Arundina, -, Yuliati, -, Pratiwi Soesilawati, -, Dian W Damaiyanti, -, Dania Maharani, -
• Format: Article PeerReviewed
• Language: Indonesian; Indonesian; Indonesian; Indonesian
• Published: Fakultas Kedokteran Gigi Universitas Airlangga 2015
• Subjects: R Medicine; RK Dentistry
• Online Access: https://repository.unair.ac.id/111023/1/the%20effects%20of%20golden%20sea%20cucumber%20extract.pdf; https://repository.unair.ac.id/111023/3/22.The%20effects%20of%20golden%20sea%20cucumber%20extract%20%28Stichopus%20hermanii%29%20%282%29.pdf; https://repository.unair.ac.id/111023/2/22.%20Pratiwi%20%28%20The%20Effects%20of%20Golden%20Sea%29%2022.pdf; https://repository.unair.ac.id/111023/6/28.Dr.Pratiwi%20%28The%20Effects%20of%20Golden%20sea%20...%29.pdf; https://repository.unair.ac.id/111023/
• Institution: Universitas Airlangga

Background: Indonesia is a country with the world’s biggest potential and producer of sea cucumbers. Golden sea cucumber contains glicosaminoglycans, such as heparan sulphate and chondroitin sulphate, which could have a positive implication on wound healing process. This acceleration of wound healing process could be observed through the increasing of lymphocytes on ulcus traumaticus. Purpose: This study aims to analyze the effects of golden sea cucumber extract on the number of lymphocytes during the healing process of traumatic ulcer on Wistar rat’s oral mucous. Method: Golden sea cucumber extrat was made with freeze-dried method, and then gel was prepared using PEG 400 and PEG 4000 solvent. Twenty male rats with mucosal ulcus made were divided into a control group and three treatment groups with 20%, 40% and 80% golden sea cucumber extracts. All samples were euthanized on day 4 and then a preparation for histopathological examination was made to examine the number of lymphocytes. Result: The biggest number of lymphocytes was found in the treatment group with 40% golden sea cucumber extract, while the lowest one was found in the control group. The results of one way Anova test then showed a significant difference between the control group and the treatment groups. And, the results of Tukey HSD showed a significant difference between the control group and the treatment group with 40% golden sea cucumber extract. Conclusion: It can be concluded that 40% golden sea cucumber (Stichopus hermanii) extract can increase the number of lymphocytes during the healing process of traumatic ulcer on Wistar rat’s oral mucous.