Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities

Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities

Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone...

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Bibliographic Details
Main Authors: Adil Astulla, -, Kazumasa Zaima, -, Yosuke Matsuno, -, Yusuke Hirasawa, -, Wiwied Ekasari, -, Aty Widyawaruyanti, -, Noor Cholies Zaini, -, Hiroshi Morita, -
Format: Article PeerReviewed
Language:English
English
English
Published: Springer Nature 2008
Subjects:
R Medicine
RS Pharmacy and materia medica
RS1-441 Pharmacy and materia medica
RS200-201 Pharmaceutical dosage forms
Online Access:https://repository.unair.ac.id/116530/1/C-09_artikel.pdf
https://repository.unair.ac.id/116530/2/C-09_peer%20review.pdf
https://repository.unair.ac.id/116530/3/C-09_similarity.pdf
https://repository.unair.ac.id/116530/
https://link.springer.com/article/10.1007/s11418-008-0259-7
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Institution: Universitas Airlangga
Language: English
English
English
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Summary:Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone (3), showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.

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