Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities

• Main Authors: Adil Astulla, -, Kazumasa Zaima, -, Yosuke Matsuno, -, Yusuke Hirasawa, -, Wiwied Ekasari, -, Aty Widyawaruyanti, -, Noor Cholies Zaini, -, Hiroshi Morita, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Springer Nature 2008
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/116530/1/C-09_artikel.pdf; https://repository.unair.ac.id/116530/2/C-09_peer%20review.pdf; https://repository.unair.ac.id/116530/3/C-09_similarity.pdf; https://repository.unair.ac.id/116530/; https://link.springer.com/article/10.1007/s11418-008-0259-7
• Institution: Universitas Airlangga

Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone...