The squamous cell carcinoma cell line OM-1 retains both p75-dependent stratified epithelial progenitor potential and cancer stem cell properties
The low-affinity nerve growth factor receptor p75 is a stratified epithelial stem/progenitor marker of human epithelia. We found OM-1, a human squamous cell carcinoma (SCC) cell line, showed distinct cells with p75 cluster, especially located at the center of a growing colony in a monolayer cultur...
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Main Authors: | , , , , , , , , , , , |
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Format: | Article PeerReviewed |
Language: | English English Indonesian English |
Published: |
2021
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Subjects: | |
Online Access: | https://repository.unair.ac.id/116759/1/12.The%20squamous%20cell%20carcinoma.pdf https://repository.unair.ac.id/116759/2/10.%20tiurnitin%20The%20squamous%20cell%20carcinoma%20cell%20line.pdf https://repository.unair.ac.id/116759/3/Artikel%2012%20Andra%20Rizqiawan.pdf https://repository.unair.ac.id/116759/6/Karil%20%2019%20Prof%20Indri%20SCC%20OM1.pdf https://repository.unair.ac.id/116759/ https://doi.org/10.1016/j.bbrep.2021.101003 |
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Institution: | Universitas Airlangga |
Language: | English English Indonesian English |
Summary: | The low-affinity nerve growth factor receptor p75 is a stratified epithelial stem/progenitor marker of human
epithelia. We found OM-1, a human squamous cell carcinoma (SCC) cell line, showed distinct cells with p75
cluster, especially located at the center of a growing colony in a monolayer culture. A cell with p75 cluster was
surrounded by cytokeratin 14- and cytokeratin 13-expressing cells that settled at the outer margin of the colony.
OM-1 cells were also capable of forming tumor spheres in a cell suspension culture, an ability which was
attenuated by the inhibition of p75-signaling. Intriguingly, we also found a p75-negative cell population from a
growing culture of OM-1 that re-committed to become p75-clustering cells. These results indicated the possibility
that SCC with epithelial multi-layering capacity can exploit the p75-dependent stratified epithelial progenitor
property for the cancer stemness. |
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