Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19

• Main Authors: Citrawati Dyah Kencono Wungu, -, Siti Khaerunnisa, -, Eka Arum Cahyaning Putri, -, Hanik Badriyah Hidayati, -, Ema Qurnianingsih, -, Lina Lukitasari, -, Ira Humairah, -, Soetjipto, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Elsevier 2021
• Subjects: R Medicine (General); RC Internal medicine
• Online Access: https://repository.unair.ac.id/117642/1/C-1%20Artikel.pdf; https://repository.unair.ac.id/117642/2/C-1%20Peer%20Review%20.pdf; https://repository.unair.ac.id/117642/3/C-1%20Turnitin.pdf; https://repository.unair.ac.id/117642/; https://www.ijidonline.com/article/S1201-9712(21)00225-3/fulltext; https://doi.org/10.1016/j.ijid.2021.03.008
• Institution: Universitas Airlangga

Objectives Previous observational studies have suggested that increased cardiac markers are commonly found in COVID-19. This study aimed to determine the relationship between several cardiac markers and the severity/mortality of COVID-19 patients. Methods Several cardiac markers were analysed in this meta-analysis. RevMan 5.4 was used to provide pooled estimates for standardised mean difference (SMD) with 95% confidence intervals. Results Twenty-nine clinical studies were included in this meta-analysis. Significantly higher CK-MB (0.64, 95% CI = 0.19–1.09), PCT (0.47, 95% CI = 0.26−0.68), NT-proBNP (1.90, 95% CI = 1.63–2.17), BNP (1.86, 95% CI = 1.63−2.09), and d-dimer (1.30, 95% CI = 0.91−1.69) were found in severe compared with non-severe COVID-19. Significantly higher CK-MB (3.84, 95% CI = 0.62−7.05), PCT (1.49, 95% CI = 0.86−2.13), NT-proBNP (4.66, 95% CI = 2.42−6.91), BNP (1.96, 95% CI = 0.78−3.14), troponin (1.64 (95% CI = 0.83−2.45), and d-dimer (2.72, 95% CI = 2.14−3.29) were found in those who died from compared with survivors of COVID-19. Conclusions High CK-MB, PCT, NT-proBNP, BNP, and d-dimer could be predictive markers for severity of COVID-19, while high CK-MB, PCT, NT-proBNP, BNP, troponin, and d-dimer could be predictive markers for survival of COVID-19 patients.