Detrimental Effect of Alprazolam on Sperm Viability ofMice (Mus musculus) Exposed to Chronic Unpredictable Mild Stress
Objective: This study aims to investigate the effect of alprazolam administration on sperm viability of mice (Mus musculus) strain Balb/C following CUMSfor 53 days. Method: This study used a true experimental design through randomization. Control group kept undisturbed without treatment and therapy...
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| Main Authors: | , , , |
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| Format: | Article PeerReviewed |
| Language: | English English English |
| Published: |
Institute of Medico-legal Publications
2021
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/117691/1/C-15%20Peer%20Review.pdf https://repository.unair.ac.id/117691/2/C-15%20Turnitin.pdf https://repository.unair.ac.id/117691/3/C-15%20Artikel-2.pdf https://repository.unair.ac.id/117691/ https://medicopublication.com/index.php/ijfmt/article/view/15805 https://doi.org/10.37506/ijfmt.v15i3.15805 |
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| Institution: | Universitas Airlangga |
| Language: | English English English |
| Summary: | Objective: This study aims to investigate the effect of alprazolam administration on sperm viability of mice (Mus musculus) strain Balb/C following CUMSfor 53 days. Method: This study used a true experimental design through randomization. Control group kept undisturbed without treatment and therapy throughout 60 days. K1 and K2 were exposed to a 53 day period of CUMS along with 7-day pretreatment adaptation. K2 was adapted for a week, stressed for 53 days along with cotreatment of alprazolam (4 mg/kg BW). Results: K1 and K2 showed insignificant improvement of sperm viability (p > 0.05).Meanwhile, K0 and K1 showed significant value compared to K2 (p<0.05). K2 showed little increase of sperm viability in CUMS group along with subsequent treatment of alprazolam. Conclusion: Overall, the results indicate an insignificant effect of alprazolam on sperm viability of CUMS-induced mice. |
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