Detrimental Effect of Alprazolam on Sperm Viability ofMice (Mus musculus) Exposed to Chronic Unpredictable Mild Stress

• Main Authors: Intan Indah Permatasari, -, Reny I'tishom, -, Hanik Badriyah Hidayati, -, Irwanto, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Institute of Medico-legal Publications 2021
• Subjects: R Medicine (General); RC Internal medicine
• Online Access: https://repository.unair.ac.id/117691/1/C-15%20Peer%20Review.pdf; https://repository.unair.ac.id/117691/2/C-15%20Turnitin.pdf; https://repository.unair.ac.id/117691/3/C-15%20Artikel-2.pdf; https://repository.unair.ac.id/117691/; https://medicopublication.com/index.php/ijfmt/article/view/15805; https://doi.org/10.37506/ijfmt.v15i3.15805
• Institution: Universitas Airlangga

Objective: This study aims to investigate the effect of alprazolam administration on sperm viability of mice (Mus musculus) strain Balb/C following CUMSfor 53 days. Method: This study used a true experimental design through randomization. Control group kept undisturbed without treatment and therapy throughout 60 days. K1 and K2 were exposed to a 53 day period of CUMS along with 7-day pretreatment adaptation. K2 was adapted for a week, stressed for 53 days along with cotreatment of alprazolam (4 mg/kg BW). Results: K1 and K2 showed insignificant improvement of sperm viability (p > 0.05).Meanwhile, K0 and K1 showed significant value compared to K2 (p<0.05). K2 showed little increase of sperm viability in CUMS group along with subsequent treatment of alprazolam. Conclusion: Overall, the results indicate an insignificant effect of alprazolam on sperm viability of CUMS-induced mice.