“The effect of allogenic freeze-dried platelet-rich plasma in increasing the number of fibroblasts and neovascularization in wound healing .”
A B S T R A C T Background: To evaluate the use of allogenic freeze-dry PRP for the full-thickness wound healing process in experimental animals (rabbits). Material and methods: This study is an experimental research using the posttest-only design, a simple randomized design. Thirty rabbits were...
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| Main Authors: | , , |
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| Format: | Article PeerReviewed |
| Language: | English Indonesian English |
| Published: |
Elsevier BV
2022
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/119383/1/12.pdf https://repository.unair.ac.id/119383/3/12.%20Validasi%20%20%28The%20Effect%20of%20slogenic...%29.pdf https://repository.unair.ac.id/119383/5/Turnitin.pdf https://repository.unair.ac.id/119383/ https://www.sciencedirect.com/science/article/pii/S2049080121011675?via%3Dihub https://doi.org/10.1016/j.amsu.2021.103217 |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian English |
| Summary: | A B S T R A C T
Background: To evaluate the use of allogenic freeze-dry PRP for the full-thickness wound healing process in
experimental animals (rabbits).
Material and methods: This study is an experimental research using the posttest-only design, a simple randomized
design. Thirty rabbits were randomly divided into six groups (three control groups and three treatment groups),
and each group consisted of five subjects. Skin-thick cuts were made on the back of each rabbit. Wounds in the
control group were treated using a paraffin gauze, and allogenic freeze-dried PRP was given to the treatment
group; observations were made on the 3rd, 9th, and 14th days. The t-test on two random samples and Man-
n–Whitney were used to process data. The results were significant at p < 0.05.
Results: There were significant differences in the average number of fibroblasts the control groups and the
treatment groups on day 3 (p = 0.009), day 9 (p = 0.023), and day 14 (p < 0.001). There were also major
differences in the average amount of neovascularization between the control group and the treatment group on
day 3 (p = 0.034), day 9 (p < 0.001), and day 14 (p < 0.001).
Conclusions: The application of allogenic freeze-dried PRP was confirmed to be able to increase the number of
fibroblasts and neovascularization in the full-thickness wound healing process in rabbits. |
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