“The effect of allogenic freeze-dried platelet-rich plasma in increasing the number of fibroblasts and neovascularization in wound healing .”

• Main Authors: Iswinarno Doso Saputro, Iswinarno, Sitti Rizaliyana, Sitti, Dhitta Aliefia Noverta, Dhitta
• Format: Article PeerReviewed
• Language: English; Indonesian; English
• Published: Elsevier BV 2022
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/119383/1/12.pdf; https://repository.unair.ac.id/119383/3/12.%20Validasi%20%20%28The%20Effect%20of%20slogenic...%29.pdf; https://repository.unair.ac.id/119383/5/Turnitin.pdf; https://repository.unair.ac.id/119383/; https://www.sciencedirect.com/science/article/pii/S2049080121011675?via%3Dihub; https://doi.org/10.1016/j.amsu.2021.103217
• Institution: Universitas Airlangga

A B S T R A C T Background: To evaluate the use of allogenic freeze-dry PRP for the full-thickness wound healing process in experimental animals (rabbits). Material and methods: This study is an experimental research using the posttest-only design, a simple randomized design. Thirty rabbits were randomly divided into six groups (three control groups and three treatment groups), and each group consisted of five subjects. Skin-thick cuts were made on the back of each rabbit. Wounds in the control group were treated using a paraffin gauze, and allogenic freeze-dried PRP was given to the treatment group; observations were made on the 3rd, 9th, and 14th days. The t-test on two random samples and Man- n–Whitney were used to process data. The results were significant at p < 0.05. Results: There were significant differences in the average number of fibroblasts the control groups and the treatment groups on day 3 (p = 0.009), day 9 (p = 0.023), and day 14 (p < 0.001). There were also major differences in the average amount of neovascularization between the control group and the treatment group on day 3 (p = 0.034), day 9 (p < 0.001), and day 14 (p < 0.001). Conclusions: The application of allogenic freeze-dried PRP was confirmed to be able to increase the number of fibroblasts and neovascularization in the full-thickness wound healing process in rabbits.