A Woman with Tuberculosis Multidrug Resistance and QTc Prolongation Repetitive Interval: A Case Report

• Main Authors: Tutik Kusmiati, Tutik, Ni Made Mertaniasih, Ni Made, Johanes Nugroho Eko Putranto, Johanes, Budi Suprapti, Budi, Soedarsono, Soedarsono, Abdul Rahman Bahmid, Abdul
• Format: Article PeerReviewed
• Language: English; English; Indonesian
• Published: Institute of Medico-Legal Publications
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/120149/1/22%20artikel.pdf; https://repository.unair.ac.id/120149/2/22%20turnitin.pdf; https://repository.unair.ac.id/120149/3/22.%20A%20Woman%20with%20Tuberculosis.pdf; https://repository.unair.ac.id/120149/; https://medicopublication.com/index.php/ijfmt/issue/view/88; https://doi.org/10.37506/ijfmt.v15i4
• Institution: Universitas Airlangga

Abstract Background : Prolonged QTc interval is one of the side effects of the short-regimen MDR-TB. QTc prolongation is a risk factor for Torsades de pointes and is influenced by many factors. Case : 47-year-old woman who was diagnosed with MDR-TB through GeneXpert examination and received short-regimen MDR-TB. This patient experienced repeated QTc prolongation, with peak QTc interval 600 msec occurring at 4th month with mild hypokalemia without clinical symptoms. The patient completed 9 months of shortregimen therapy with improve chest x ray followed by negative sputum culture. Conclusion : Short-regimen MDR-TB contains several drugs that cause QTc prolongation. Clinical evaluation is required in patients with QTc prolongation before changing the regiment.