Sifat Antioksidan Bawang Putih (Allium Sativurn) Yang Berperan Sebagai Hepatoprotektor Pada Tikus Putih (Rattus Norvegicus Galur Sprague Dawley) Yang Diinduksi Dengan Cci4

• Main Author: Nove Hidajati, -
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian
• Published: 2001
• Subjects: SF600-1100 Veterinary medicine; Including veterinary genetics, ethology, anatomy, physiology, embryology, pathology; SF780.2-780.7 Veterinary microbiology, bacteriology, virology, mycology
• Online Access: https://repository.unair.ac.id/120861/1/KKB%20KK%20TKD%2024-01%20Hid%20S.pdf; https://repository.unair.ac.id/120861/; http://www.lib.unair.ac.id
• Institution: Universitas Airlangga

This study was aimed to identify the role of garlic as antioxidant and hepatoprotector on CCI4-induced rat. Experimental laboratory method was used in this study. Three different treatments (garlic extract of 2.5 g/kg bw, 5 g/kg bw, and 10 glkg bw) were given everyday for 8 days. Two control, negative and positive, were used for comparison. MDA (malondialdehyde) examination was performed using TBA (thiobarbituric acid) test, serum GPT (glutamate pyruvate transaminase ) , and histopathological examination. Results showed that garlic administration of 10 g/kg bw could prevent the increase of MDA concentration, the occurrence of centrilobular necrosis, and the increase of GPT concentration. It indicated that garlic dose of 10 g/kg bw had antioxidant and hepatoprotective activity on CCI4-induced rat.