Correlation of HIF-1α, CXCR4 and MMP13 Expression in Laryngeal Squamous Cell Carcinoma with Cervical Nodal Status
Abstract Background: Laryngeal carcinoma is the most common malignancy of the upper respiratory tract, more than 98% are squamous cell carcinoma (SCC). New method is necessary for identifying and αpredicting nodal metastasis in laryngeal SCC. Overproliferating tumor cells will induce hypoxia and re...
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| Main Authors: | , , , , , , |
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| Format: | Article PeerReviewed |
| Language: | English Indonesian English Indonesian Indonesian |
| Published: |
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| Online Access: | https://repository.unair.ac.id/122579/1/20%20ARTIKEL.pdf https://repository.unair.ac.id/122579/2/20%20etik.pdf https://repository.unair.ac.id/122579/4/20%20turnitin.pdf https://repository.unair.ac.id/122579/9/Karil%20%281%29-20.pdf https://repository.unair.ac.id/122579/11/19%20karil.pdf https://repository.unair.ac.id/122579/ https://medicopublication.com/index.php/ijfmt/article/view/18426 https://doi.org/10.37506/ijfmt.v15i4.18426 |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian English Indonesian Indonesian |
| Summary: | Abstract
Background: Laryngeal carcinoma is the most common malignancy of the upper respiratory tract, more than 98% are squamous cell carcinoma (SCC). New method is necessary for identifying and αpredicting nodal metastasis in laryngeal SCC. Overproliferating tumor cells will induce hypoxia and release HIF-1α, which in turn will upregulate CXCR4. CXCR4 then will induce MMP13, a protein that degrade extracellular matrix (ECM), thus promoting metastatic process.
Methods: A cross sectional study, using 30 samples of laryngeal SCC, divided into two groups: based on cervical lymph node status. All samples were stained immunohistochemically against HIF-1α, CXCR4 and MMP13 antibody. The expressions were evaluated using immunoreactive score (IRS).
Result: There were significant difference among HIF1α, CXCR4, and MMP13 in laryngeal SCC with positive nodal metastasis group compared to negative nodal metastasis group (p<0,05).
Conclusion: There were significant differences in HIF-1α, CXCR4 and MMP13 immunoexpression in laryngeal SCC with cervical nodal metastasis compared to laryngeal SCC without cervical nodal metastasis. There was a positive correlation between HIF-1α and MMP13 expression, positive correlation between CXCR4 and MMP13 expression, but there was no correlation between HIF-1α and CXCR4 expression. |
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