Bisacodyl overcomes morphine-induced constipation by decreasing colonic Aquaporin-3 and Aquaporin-4 expression

• Main Authors: Mahardian Rahmadi, -, Chrismawan Ardianto, -, Ahmad Dzulfikri Nurhan, -, Rafiqa Amalia Chasanah, -, Dewi Islamiah Krismonika, -, Arina Dery Puspitasari, -, Budi Suprapti, -, Santhra Segaran, -, Chia-Wei Phan, -, Junaidi Khotib, -
• Format: Article PeerReviewed
• Language: English; English; English; English; English; English; English
• Published: Belgorod State National Research University 2022
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/123512/1/C-01%20Artikel.pdf; https://repository.unair.ac.id/123512/8/C-01%20Kualitas%20Karil.pdf; https://repository.unair.ac.id/123512/4/C-01%20Similirity.pdf; https://repository.unair.ac.id/123512/2/C-01%20Bukti%20Korespondensi.pdf; https://repository.unair.ac.id/123512/10/Artikel%20C-28.pdf; https://repository.unair.ac.id/123512/11/%28C-28%29%20Kualitas%20Karil.pdf; https://repository.unair.ac.id/123512/12/Similarity%20C-28.pdf; https://repository.unair.ac.id/123512/; https://rrpharmacology.ru/index.php/journal/article/view/93; https://doi.org/10.3897/rrpharmacology.8.82242
• Institution: Universitas Airlangga

Introduction: Morphine is an opioid prescribed to treat aches and pains. However, morphine often causes opioid-induced constipation (OIC). Aquaporin (AQP) transporters, especially AQP3 and AQP4, play an essential role in mediating constipation. Bisacodyl is a common laxative used to treat constipati...